Associate Director, Drug Discovery Toxicologist

Description

About Us

Exscientia is an AI-driven pharmatech company committed to discovering, designing and developing the best possible drugs in the fastest and most effective manner. Exscientia developed the first-ever functional precision oncology platform to successfully guide treatment selection and improve patient outcomes in a prospective interventional clinical study, as well as to progress AI-designed small molecules into the clinical setting.

Our pipeline demonstrates our ability to rapidly translate scientific concepts into precision-designed therapeutic candidates, with more than 15 projects underway. By designing better drugs, faster, we believe the best ideas of science can rapidly become the best medicines for patients.

The Role

The Discovery Toxicologist will join the innovative Preclinical Development group and will provide project teams with scientific expertise and leadership for the safety assessment of Exscientia programs from early discovery, through to candidate selection and beyond. You will contribute to the assessment and selection of novel drug targets and optimisation of novel candidate molecules using innovative molecular, cellular and in vivo technologies to maximise predictive safety science and investigative toxicology.

Please note this is a hybrid role but occasional travel may be required to our offices in Vienna (AT) or Oxford (UK) (approximately 1-2 times per quarter), with flexibility to work from home the remaining time.

You will have the opportunity to:

• Represent Toxicology as the Subject Matter Expert on cross-functional project teams within the Discovery organisation. Opportunity to represent Toxicology in Development as the projects progress.
• Act as a key resource for early safety assessment during the drug discovery phase, providing scientific knowledge and expertise to cross-functional project teams.
• Use established toxicology screening strategies to predict, assess and mitigate target- and drug-related safety risks in support of the drug discovery portfolio.
• Refine and implement innovative experimental strategies and use the data to assess and /or provide mechanistic understanding of safety issues.
• Collaborate with CROs to ensure best practice for in vitro and/or in vivo safety assessment.
• Prepare verbal and written summaries for internal discussions. Work with the Discovery teams to develop optimal strategies to address specific safety issues within project teams. Present summary data to project teams, Exscientia senior leadership and external partners as needed.

Requirements

Essential skills:

• DVM, Pharm D, Ph.D in toxicology, Pathology, Physiology, Biochemistry or expertise in related biological scientific disciplines, with an emphasis on Oncology/Immunology is preferred. 10+ years experience in safety sciences in the Biotech/Pharma industry
• Experience in project team membership as a Discovery toxicology representative in a matrix environment
• Experience with in silico and in vitro safety assessment leading to an in-depth knowledge of discovery toxicology, and experience designing and critically evaluating results of exploratory toxicology studies
• An understanding of in vitro to in vivo translation of potential toxicities and implications for human safety
• Broad background in novel methods of identifying potential toxicities and developing risk mitigation plans
• Highly motivated scientist, who can work independently, with excellent oral/written communication skills

Desirable skills:

• Board Certification in Toxicology (DABT/ERT)
• Experience running in vivo safety assessment studies
• Knowledge of secondary pharmacology assessment and mitigation of identified risks
• Keen interest in artificial intelligence and its application to drug discovery. Experience with the use of AI-tools to predict toxicology endpoints.

Please use the below link for job application and quicker response:

https://lifelancer.com/jobs/view/04628cf5d3a017643f50f7453a36b4b6