Invitro ADME Scientist

Date: 21 Jul 2025

Location:

Bangalore, KA, IN, 560099

Custom Field 1: Discovery Services

Designation: Invitro ADME Sientist

Job Location: Bangalore/Hyderabad

Department: Discovery Biology

About Syngene: Syngene (www.syngeneintl.com) is an innovation-led contract research, development and manufacturing organization offering integrated scientific services from early discovery to commercial supply.

At Syngene, safety is at the heart of everything we do personally and professionally. Syngene has placed safety at par with business performance with shared responsibility and accountability, including following safety guidelines, procedures, and SOPs, in letter and spirit

Mandatory expectation for all roles as per Syngene safety guidelines:

• Overall adherence to safe practices and procedures of oneself and the teams aligned
• Contributing to development of procedures, practices and systems that ensures safe operations and compliance to company’s integrity & quality standards
• Driving a corporate culture that promotes environment, health, and safety (EHS) mindset and operational discipline at the workplace at all times.
• Ensuring safety of self, teams and lab/plant by adhering to safety protocols and following environment, health, and safety (EHS) requirements at all times in the workplace.
• Ensure all assigned mandatory trainings related to data integrity, health, and safety measures are completed on time by all members of the team including self.
• Compliance to Syngene’ s quality standards at all times.
  
  

Job Purpose

• Support the ADME team by planning and conducting the metabolic stability, Single point inhibition, reversible CYPIC50 inhibition and TDI-IC50 shift assays using Human liver microsomes with highest quality
• Time management and multi-tasking skills to meet the demand of high-volume wave 1 ADME assays to complete multiple projects within timelines.
• Contemporaneous recording of lab activities and experiments performed, practices high level of house keeping
• Adhere to all safety rules and maintains safe workplace.
• Predominantly laboratory-based job
  
  

Key Responsibilities

• Extensive experience in planning metabolic stability, CYP inhibition assays
• Design and execute in-vitro Single point inhibition, reversible CYPIC50 inhibition and TDI-IC50 shift assay with human liver microsomes.
• Seamless coordination with BA-DMPK group to design in-vitro CYP inhibition studies.
• Preparation of SOP’s and EOPs.
• Reporting of executed studies without any noncompliance.
• Reporting of study results clearly in the cross functional scientific meetings.
• Follow environment, health, and safety (EHS) requirements at all times in the workplace ensuring individual and lab/plant safety.
• Ensure environment, health, and safety (EHS) measures are imparted via training and adhered within the team.
  
  

Educational Qualification

• M Pharm. in any pharmaceutical science or M Sc. in biological science or PHD.
  
  

Technical/functional Skills

Comprehensive understanding of in vitro ADME assays and technical expertise in trouble shooting the assays

• In depth understanding of biochemical and aspects of enzyme kinetics is highly desirable related to the metabolism
• Good, demonstrated knowledge in software such as Microsoft excel and Graph pad prism
• Demonstrated cross functional leadership capabilities
• Experience with automation is desirable
  
  

Experience

• M Pharm. in pharmaceutical sciences or M SC in biological science or PHD with 1-15 years of Industrial experience in DMPK/ADME research.
  
  

Behavioral Skills

• Demonstrate ability to be a team player.
• Commitment to deliver the study reports within the agreed timelines
• Adaptability to changes in the dynamic lab environment
• Communicate confidently with colleagues and collaborators in the meetings and presentation of study reports and evidence of publications in the PEER reviewed Journals
  
  

Equal Opportunity Employer

It is the policy of Syngene to provide equal employment opportunity (EEO) to all persons regardless of age, color, national origin, citizenship status, physical or mental disability, race, religion, creed, gender, sex, sexual orientation, gender identity and/or expression, genetic information, marital status, status with regard to public assistance, veteran status, or any other characteristic protected by applicable legislation or local law. In addition, Syngene will provide reasonable accommodations for qualified individuals with disabilities.